tilidin al comp 100/8 - An Overview
After oral administration, tilidine is speedily absorbed. It's subject matter to a pronounced 1st-pass influence. The conversion of tilidine to the greater potent active metabolite nortilidine occurs Along with the involvement of CYP3A4 and CYP2C19. Inhibition of those enzymes may possibly So change the efficacy and tolerability profile of tilidine